Techsploitation
By Annalee Newitz
Staying
alive
PROSTITUTION MAY BE the oldest profession on Earth, but the
oldest science on Earth is no doubt the study of longevity. The earliest
stirrings of rational inquiry in civilizations like ancient Egypt's
were bound up with the quest for immortality. And while the Egyptians
may not have had National Institutes of Health grants, or immortal mummies,
they certainly managed to come up with some groovy chemical compounds
that preserve dead bodies for a really long time.
In San Francisco two of the oldest pursuits in the world are thriving
within blocks of each other: sex workers sell their services along Sixth
Street, while a biology laboratory devoted to life extension, the Kenyon
Lab, was one of the first to move into UC San Francisco's new Mission
Bay digs off Seventh Street. Directed by the notoriously quirky Cynthia
Kenyon, the lab has been making headlines for the past couple of years
with a string of discoveries involving the genetic basis for
aging. While many researchers have argued that the key to extending
life span is caloric restriction essentially, starving oneself
Kenyon has proved that aging can be slowed significantly simply
by interfering with the way our genomes control the processing of certain
hormones.
In a recent interview in New Scientist, Kenyon said, "Longevity
is evolvable. The common precursor to worms, flies, mice and humans
was a very simple, short-lived animal. And to get from a worm to a human
you have increased life span a thousandfold. This happened by changes
in genes." Her argument is as commonsensical as it gets: given
that certain animals have evolved long life spans, it follows logically
that longevity is something that is controlled by genetics.
Another implication of Kenyon's work is that we don't grow old and
die just because we run down like machines do. We do it because our
genes tell our bodies to at a certain point much the same way
they tell us to go through puberty or to get taller as we age.
Kenyon, along with other antiaging geeks like Lenny Guarente at the
Massachusetts Institute of Technology, are convinced we can invent drugs
that mess around with the genes that kick off the aging cycle
in the case of humans, we're talking mostly about genes that help create
parts of our cells that interact with insulin and another hormone called
insulin-like growth factor. Kenyon Lab experiments reveal that if you
mutate equivalent genes in C. elegans, every biologist's favorite
little worm, the nematodes live as much as four times longer than their
nonmutant peers.
This is exciting but dangerous news. Sure, it's cool in a nerdy way
to discover that aging is controlled by genes. But more than that, it's
lucrative. With a handful of other prominent scientists in the field,
Kenyon is a cofounder of Cambridge, Mass.-based bio-com Elixir Pharmaceuticals,
where researchers are trying to produce drugs that would extend human
life the way Kenyon extended the lives of her C. elegans research
subjects. If Elixir can discover such a drug, the market would literally
be infinite. Everybody wants to live longer. That's the whole basis
for practically every religion on our dumb, dirty planet: eternal afterlife,
eternal reincarnation, etc. It's all about getting more time to be our
fabulous selves.
So why does the idea of a life-extending drug repulse me? Partly it's
the obvious problem that this will be an amenity for the wealthier members
of our species, which is patently unfair. Why should Bill Gates get
to live longer than Jim Munroe or Seth Schoen? Munroe and Schoen have
done far more good in the world on shoestring budgets than Gates has
done with his global corporate domination scam.
Also, I think extending certain people's lives might be nice for a
few select individuals but would be extremely destructive for us as
a species. Given that the human population is expanding far beyond our
ability to maintain a decent quality of life for most people, doesn't
the pursuit of longevity seem, well, selfish? Although the idea of taking
pills to stay alive an extra 100 years is tempting, the idea of popping
one makes me feel profoundly guilty.
Life is good, but only if everybody has equal access to it. Maybe someday
we'll have solved enough problems in our respective societies that I
can suck up the world's resources for an extra 100 years without repercussions.
But we're not there yet.
Annalee Newitz (notimmortal@techsploitation.com)
is a surly media nerd who thinks guilt is sometimes the only moral guide
she has. Her column also appears in Metro, Silicon Valley's weekly newspaper.